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. Author manuscript; available in PMC: 2021 Mar 27.
Published in final edited form as: J Mol Biol. 2020 Feb 24;432(7):2271–2288. doi: 10.1016/j.jmb.2020.02.014

Fig. 2. Comparison of native and DRIP-enriched SMRF-seq profiles.

Fig. 2.

(A) SMRF-seq profiles are shown for the nontemplate strand of the FUS amplicon without and with S.6 enrichment (top and bottom, respectively). Two hundred twenty-six molecules are shown in both panels corresponding to the totality of footprints in the absence of S9.6 and to a random subsample after S9.6 enrichment. The plots below depict the aggregate C to T conversion frequencies observed for each sample over R-loop-containing molecules. (B) Similar data as in previous panel for the RPS24 locus. Two hundred fifty-eight independent molecules are shown in both panels corresponding to the totality of footprints in the absence of S9.6 and to a random subsample after S9.6 enrichment.