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The correlation between the activity of ADE and related ND. Different from NEP, IDE, and ADAM10, inhibition of AEP could be a strategy to care AD and PD.
| Related neurodegenerative diseases | Enzymes | Results of enhanced enzyme activity | Amyloid aggregation |
|---|---|---|---|
| AD | NEP | Aβ degradation ↑ | Aβ aggregation ↓ |
| AD | IDE | Aβ degradation ↑ | Aβ aggregation ↓ |
| AD, PD | AEP | Tau/α-Syn fragmentation ↑ | Tau/α-Syn aggregation ↑ |
| AD | ADAM10 | Aβ generation ↓ | Aβ aggregation ↓ |
