Table 3.
Circulating biomarkers in patients and in the control group.
| Parameters | Control group (n = 13) Me (25, 75) | Group 1 without HF (n = 20) Me (25, 75) | Group 2 HFpEF (n = 29) Me (25, 75) | Group 3 HFmrEF (n = 13) Me (25, 75) | p for gr. 1, 2, and 3 | p for gr. 1 vs. 2 | p for gr. 1 vs. 3 | p for gr. 2 vs. 3 |
|---|---|---|---|---|---|---|---|---|
| Nt-proBNP pg/ml | — | 52.4 (14.5, 104.3) | 133.6 (78.5, 198.5) | 162.5 (134.6, 216.7) | 0.005 | 0.005 | 0.003 | 0.03 |
| sST-2, ng/ml | 18.3 (15.6, 21.2) | 19.2 (16.2, 26.3) | 19.9 (12.9, 40.7) | 19.6 (13.8, 37.1) | 0.97 | 0.89 | 0.77 | 0.28 |
| Galectin-3, ng/ml | 5.7+ (4.9, 6.3) | 8.6 (7.2, 10.8) | 11.7 (8.1, 13.4) | 10.4 (7.9, 14.0) | 0.03 | 0.01 | 0.03 | 0.84 |
| PICP, ng/ml | 15.0+ (10.0, 34.0) | 127.4 (113.3, 170.2) | 46.8 (22.6, 98.6) | 106.4 (85.4, 140.4) | 0.005 | 0.006 | 0.09 | 0.043 |
| PIIINP, ng/ml | 1.27+ (0.67, 3.18) | 3.38 (2.85, 3.61) | 3.29 (1.96, 4.59) | 3.46 (2.24, 4.97) | 0.58 | 0.68 | 0.49 | 0.38 |
| PICP/PIIINP | 7.4+ (3.7, 8.4) | 35.3 (30.1, 44.4) | 18.4 (14.6, 25.3) | 31.5 (25.8, 40.1) | 0.07 | 0.017 | 0.35 | 0.033 |
| MMP-9, ng/ml | 540.0 (363.0, 669.0) | 412.5 (289.5, 687.7) | 277.0# (98.5, 403.5) | 257.0 # (152.0, 483.5) | 0.12 | 0.26 | 0.11 | 0.51 |
| TIMP-1, ng/ml | 149.0 (133.0, 170.0) | 208 (172, 241) | 178.5 (119.5, 210.7) | 154 (114.7, 203.5) | 0.16 | 0.21 | 0.05 | 0.81 |
| MMP-9/TIMP-1 | 3.6+ (2.3, 5.2) | 1.6 (1.2, 2.8) | 1.1 (0.6, 3.6) | 0.8 (0.42, 3.1) | 0.31 | 0.44 | 0.39 | 0.5 |
| hsCRP, mg/l | — | 2.1 (0.8, 4.9) | 2.5 (1.7, 5.9) | 3.3 (2.0, 7.3) | 0.41 | 0.29 | 0.31 | 0.61 |
+ р < 0.05 (between control group and investigated groups); #р < 0.03 (between control group and groups 2 and 3).