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. 2020 Jul 15;8(11):2259–2264. doi: 10.1002/ccr3.3133

TABLE 2.

Bazex syndrome case details

Case 1 Case 2 Case 3
Patient 1 2 3
Age/Race/Sex 60 yo/Caucasian/Male 55 yo/Caucasian/Female 48 yo/African American/Male
Risk factors Alcohol, 80 py smoking history 7.5 py smoking history 1.25 py smoking history
Disease site Hypopharynx Oropharynx (p16 negative) Hypopharynx
Histology Squamous Cell Carcinoma Squamous Cell Carcinoma Squamous Cell Carcinoma
Clinical presentation

Figure 1

Skin: hands, feet, and ears with burning and itching

Nails: Dryness, flaking, and thickening of fingernails

Stress worsened symptoms

Figure 2

Skin: Raynaud's‐like symptoms with pallor and numbness and focal necrosis of the tip of the right third finger

Nails: Raised, brittle yellow, and thickened

Figure 3

Skin: Diffuse thickening and scaling of palms and soles

Dry hyperpigmented patches on the anterior shins

Nails: Not affected

Skin biopsy Hyperkeratosis, horn cysts with focal intracorneal acute inflammation, psoriaform dermatitis Not performed Not performed
Timing of symptoms Oncologic and dermatologic sx's developed around same time Dermatologic sx's preceded oncologic sx's by ~6 mo Oncologic sx's preceded dermatologic sx's by ~1 mo
Treatment

Oncologic: Definitive chemoradiation to 70Gy with concurrent cisplatin

Dermatologic: Acitretin

Oncologic: Definitive chemoradiation to 70 Gy with concurrent cisplatin

Dermatologic: Acitretin, clotrimazole/betamethasone, and nitroglycerin

Oncologic: Definitive chemoradiation to 70Gy with concurrent cisplatin/carboplatin

Dermatologic: Triamcinolone and topical urea

Cancer outcome Patient remains NED 46 mo post‐treatment Patient remains NED 40 mo post‐treatment Died 7 mo post‐treatment due to disease progression and metastases
Bazex symptom outcome

Figure 1

Complete resolution with intermittent flare ups responsive to acitretin

Figure 2

Complete resolution with no flare ups

Figure 3

Complete resolution seen in hands but only partial resolution in legs and foot

Abbreviations: Gy, gray; NED, no evidence of disease; py, pack‐year; Sx's, symptoms; yo, year old.