Table 4.

Subgroup-Analyses Between CNR1 Rs10493353 Gene Polymorphism and DN

Variables	rs10493353 (Case/Control)			AA vs GG		GA vs GG		AA/GA vs GG		AA vs GA/GG		A vs G
	GG	GA	AA	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Gender
Male	105/67	39/42	13/26	0.32 (0.15–066)	0.002	0.59 (0.35–1.01)	0.054	0.49 (0.30–0.78)	0.003	0.38 (0.19–0.77)	0.007	0.49 (0.34–0.71)	0.001
Female	120/104	33/62	10/19	0.46 (0.20–1.03)	0.057	0.46 (0.28–0.76)	0.002	0.46 (0.29–0.72)	0.001	0.57 (0.60–1.27)	0.168	0.52 (0.36–0.76)	0<0.001
Hypertension
Yes	74/43	27/23	6/13	0.27 (0.10–0.76)	0.013	0.68 (0.35–1.33)	0.264	0.53 (0.29–0.97)	0.041	0.30 (0.11–0.83)	0.021	0.50 (0.31–0.80)	0.004
No	151/128	45/81	17/32	0.43 (0.24–0.85)	0.014	0.47 (0.31–0.73)	0.001	0.47 (0.32–0.69)	<0.001	0.57 (0.31–1.05)	0.072	0.53 (0.39–0.72)	<0.001
Smoking
Yes	73/34	24/27	6/9	0.31 (0.11–0.94)	0.039	0.41 (0.21–0.82)	0.012	0.38 (0.21–0.73)	0.003	0.42 (0.14–1.24)	0.115	0.45 (0.27–0.74)	0.002
No	152/137	48/77	17/36	0.43 (0.23–0.79)	0.007	0.56 (0.37–0.86)	0.008	0.52 (0.35–0.76)	0.001	0.51 (0.28–0.93)	0.028	0.55 (0.40–0.75)	<0.001
Drinking
Yes	82/41	23/21	10/13	1.61 (0.44–5.86)	0.470	0.64 (0.32–1.28)	0.209	0.49 (0.26–0.89)	0.020	0.45 (0.19–1.09)	0.080	0.50 (0.31–0.81)	0.005
No	143/130	49/83	13/32	0.32 (0.17–0.61)	0.001	0.54 (0.35–0.83)	0.004	0.47 (0.32–0.69)	<0.001	0.39 (0.21–0.74)	0.004	0.16 (0.11–0.22)	<0.001
BMI
≥24	50/46	21/30	7/4	0.1 (0.03–0.61)	0.010	0.74 (0.35–1.56)	0.435	0.76 (0.40–1.44)	0.396	1.87 (0.53–6.67)	0.333	0.93 (0.55–1.57)	0.782
<24	175/125	51/74	16/41	0.28 (0.15–0.52)	<0.001	0.49 (0.32–0.75)	0.001	0.42 (0.29–0.61)	<0.001	0.34 (0.19–0.63)	0.001	0.43 (0.32–0.58)	<0.001
Diuretics
Yes	66/63	17/36	5/13	0.37 (0.12–1.09)	0.071	0.45 (0.23–0.88)	0.020	0.43 (0.23–0.79)	0.006	0.49 (0.16–1.34)	0.154	0.47 (0.29–0.78)	<0.001
No	159/108	55/68	18/38	0.38 (0.20–0.72)	0.003	0.55 (0.36–0.85)	0.006	0.50 (0.34–0.73)	<0.001	0.46 (0.25–0.85)	0.013	0.48 (0.35–0.65)	<0.001