Table 5.
Interactions Between Gene and Environmental Factors Analysis
| Gene | Environment | Case | Control | OR (95% CI) | Reflecting Information |
|---|---|---|---|---|---|
| AA/GG | Smoking | ||||
| – | – | 152 | 137 | 1.00 | E (-), the role of G |
| - | + | 73 | 34 | 1.94 (1.21–3.09) | E (+), the role of G |
| + | - | 17 | 36 | 0.43 (0.23–0.79) | G (-), the role of E |
| + | + | 6 | 9 | 0.60 (0.21–1.73) | G (+), the role of E |
| GA/GG | Smoking | ||||
| - | - | 152 | 137 | 1.00 | E (-), the role of G |
| - | + | 73 | 34 | 1.94 (1.21–3.09) | E (+), the role of G |
| + | - | 48 | 77 | 0.56 (0.37–0.86) | G (-), the role of E |
| + | + | 24 | 27 | 0.80 (0.44–1.45) | G (+), the role of E |
| AA/GG | Drinking | ||||
| - | - | 143 | 130 | 1.00 | E (-), the role of G |
| - | + | 82 | 41 | 1.82 (1.17–2.83) | E (+, the role of G |
| + | - | 13 | 32 | 0.37 (0.19–0.73) | G (-), the role of E |
| + | + | 10 | 13 | 0.70 (0.30–1.65) | G (+), the role of E |
| GA/GG | Drinking | ||||
| - | - | 143 | 130 | 1.00 | E (-), the role of G |
| - | + | 82 | 41 | 1.82 (1.17–2.83) | E (+), the role of G |
| + | - | 49 | 83 | 0.54 (0.35–0.82) | G (-), the role of E |
| + | + | 23 | 21 | 1.00 (0.53–1.88) | G (+), the role of E |
| AA/GG | BMI | ||||
| - | - | 175 | 125 | 1.00 | E (-), the role of G |
| - | + | 50 | 46 | 0.78 (0.49–1.23) | E (+), the role of G |
| + | - | 16 | 41 | 0.28 (0.15–0.52) | G (-), the role of E |
| + | + | 7 | 4 | 1.25 (0.36–4.36) | G (+), the role of E |
| GA/GG | BMI | ||||
| - | - | 175 | 125 | 1.00 | E (-), the role of G |
| - | + | 50 | 46 | 0.78 (0.49–1.23) | E (+), the role of G |
| + | - | 51 | 41 | 0.89 (0.55–1.42) | G (-), the role of E |
| + | + | 21 | 30 | 0.50 (0.27–0.91) | G (+), the role of E |
| AA/GG | Hypertension | ||||
| - | - | 151 | 128 | 1.00 | E (-), the role of G |
| - | + | 74 | 43 | 1.46 (0.94–2.27) | E (+), the role of G |
| + | - | 17 | 32 | 0.45 (0.24–0.85) | G (-), the role of E |
| + | + | 16 | 13 | 1.04 (0.48–2.25) | G (+), the role of E |
| GA/GG | Hypertension | ||||
| - | - | 151 | 128 | 1.00 | E (-), the role of G |
| - | + | 74 | 43 | 1.46 (0.94–2.27) | E (+), the role of G |
| + | - | 45 | 81 | 0.47 (0.31–0.73) | G (-), the role of E |
| + | + | 27 | 23 | 1.00 (0.54–1.82) | G (+), the role of E |