Table 4.

Cox Proportional Hazard Models on PFS and OS of NPC Patients

	Progression-Free Survival						Overall Survival
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Age, year (≥46 vs <46)	1.49	0.86–2.58	0.159				1.50	0.89–2.53	0.128
Sex (female vs male)	0.40	0.19–0.86	0.018*	0.41	1.38–6.33	0.039*	0.76	0.41–1.38	0.363
Smoking (No vs Yes)	0.52	0.30–0.90	0.019*	1.42	0.77–2.63	2.265	1.36	0.81–2.29	0.239
Alcohol taking (No vs Yes)	1.66	0.93–2.97	0.090				1.26	0.71–2.24	0.430
Clinical classification (III–IV vs I–II)	3.12	1.33–7.33	0.009*	0.66	0.18–2.45	0.534	4.15	1.66–10.39	0.002*	1.70	0.48–6.03	0.412
T classification (T3-4 vs T1-2)	2.38	1.34–4.23	0.003*	3.15	1.35–7.36	0.007*	2.38	1.34–4.23	0.003*	1.61	0.78–3.30	0.196
N classification (N2-3 vs N0-1)	2.83	1.51–5.30	0.001*	2.55	1.29–5.02	0.008*	2.58	1.49–4.48	0.001*	1.752	0.90–3.42	0.101
M classification (M1 vs.M0)	1.25	0.17–9.14	0.828				9.88	4.61–21.16	<0.001*	6.01	2.66–13.57	<0.001*
CD163 density (high vs low)	1.81	1.03–3.17	0.038*	1.23	0.67–2.26	0.513	1.94	1.13–3.31	0.016*	1.07	0.59–1.94	0.818
CD68 density (high vs low)	1.02	0.59–1.76	0.952				1.17	0.68–1.96	0.555
PD-L1 (positive vs negative)	0.80	0.46–1.38	0.416				0.75	0.45–1.26	0.279

Note: *p<0.05.