Table 4.
Clinical Outcome Correlation of NTRK2 Polymorphisms with is Patients
| Feature | Genotype (rs11140793) | AC vs AA* P value |
CC vs AA* P value |
||
|---|---|---|---|---|---|
| AA | AC | CC | |||
| NIHSS ac (Mean/SD) | 3.1/1.1 | 4.2/1.5 | 4.8/1.1 | 0.02 | 0.005 |
| NIHSS 3m (Mean/SD) | 0.6/0.1 | 0.8/0.2 | 1.1/0.2 | 0.03 | 0.002 |
| tHcy (mmol/L) | 12.3/1.8 | 13.5/1.5 | 15.5/1.4 | 0.01 | 0.001 |
| NTRK2 (Mean/SDb) | 0.08/0.022 | 0.06/0.018 | 0.04/0.11 | 0.02 | 0.003 |
| Feature | Genotype (rs7047042) |
CG vs CC* P value |
GG vs CC* P value |
||
| CC | CG | GG | |||
| NIHSS ac (Mean/SD) | 3.2/1.1 | 3.5/1.3 | 4.1/2.1 | 0.04 | 0.02 |
| NIHSS 3m (Mean/SD) | 0.7/0.1 | 0.9/0.2 | 1.0/0.2 | 0.03 | 0.01 |
| tHcy (mmol/L) | 11.8/1.9 | 12.1/1.6 | 14.2/1.8 | 0.01 | 0.04 |
| NTRK2 (Mean/SDb) | 0.09/0.012 | 0.06/0.021 | 0.04/0.19 | 0.02 | 0.03 |
| Feature | Genotype (rs1221) |
CT vs CC* P value |
TT vs CC* P value |
||
| CC | CT | TT | |||
| NIHSS ac (Mean/SD) | 3.5/1.1 | 3.6/1.7 | 4.2/2.1 | 0.12 | 0.03 |
| NIHSS 3m (Mean/SD) | 1.1/0.4 | 1.1/0.6 | 1.3/0.8 | 0.23 | 0.02 |
| tHcy (mmol/L) | 10.8/1.9 | 13.2/0.2 | 13.1/0.3 | 0.001 | 0.002 |
| NTRK2 (Mean/SDb) | 0.06/0.032 | 0.03/0.021 | 0.01/0.011 | 0.01 | 0.03 |
Notes: *Student t-test for either genotype distributions or allele frequencies in IS patients. bRelative expression of NTRK2 normalized with GAPDH. NIHSS ac, initial stroke severity during the acute phase; NIHSS 3m, stroke severity after 3 months; MTHFR: Relative expression of MTHGR mRNA in IS patients.