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. 2020 Nov 12;15:8875–8892. doi: 10.2147/IJN.S270208

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© 2020 Lu et al.

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Schematic illustration of the TAT-AT7-modified PEI polymer delivery system encapsulating the angiogenesis-inhibiting secretory endostatin gene (PPTA/pVAXI-En) as an antiglioma therapy. PPTA/pVAXI-En could efficiently penetrate the BBB and BTB, showed high level of accumulation in glioma tissue and specifically bound VEGFR-2 and NRP-1 expressed on endothelial cells and glioma cells.