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. Author manuscript; available in PMC: 2021 May 15.
Published in final edited form as: Clin Cancer Res. 2020 Jun 17;26(22):5781–5790. doi: 10.1158/1078-0432.CCR-20-0572

Figure 2: Target identification and inhibition for short-term and long-term cultures.

Figure 2:

Tumors were irradiated with single dose (SD) or multifractionated (MF) irradiation. Within the first 24 h, short-term changes in mRNA, protein phosphorylation and metabolism were examined. (A) Activated AKT-mTOR signaling was (B) targeted with a small molecule AKT inhibitor (AKTi) Additionally, long-term changes in target expression were evaluated after tumor regrowth. (C) At 2 months after irradiation, β1 integrin was overexpressed in prostate cancer cells. (D) Inhibition of β1 integrin (ITGB1i) resulted in decreased clonogenic survival of MF-irradiated cells.