Table 3.
Associations with probable RBD in CTE participants without Lewy pathology
| Characteristic | No pRBD | pRBD | P value |
|---|---|---|---|
| Sample size (n) | 139a | 54b | - |
| Age, mean (SD), y | |||
| Cognitive symptom onset | 50.1 (19.8) | 52.7 (16.3) | 0.41 |
| Death | 58.9 (20.5) | 62.0 (16.9) | 0.33 |
| Contact sport exposure, mean (SD), y | |||
| Age of First Exposure | 11.0 (3.9) | 11.2 (3.0) | 0.75 |
| Total Years of Play | 15.0 (6.1) | 18.0 (9.9) | 0.02 |
| Presence of NFTs, yes/no (% yes) | |||
| Dorsal/median raphe nuclei | 90/46 (66.2) | 41/8 (83.7) | 0.02 |
| Locus coeruleus | 119/14 (89.5) | 47/4 (92.2) | 0.58 |
| Subcoeruleus | 75/57 (56.8) | 29/21 (58.0) | 0.89 |
| Basis pontis | 42/96 (30.4) | 15/35 (30.0) | 0.95 |
| Substantia nigra | 95/41 (69.9) | 41/13 (75.9) | 0.40 |
LBD Lewy body disease; pRBD probable REM sleep behavior disorder; NFT neurofibrillary tangle; CTE chronic traumatic encephalopathy
a
Of the 139 participants without pRBD, sample sizes were reduced to 136 for dorsal/median raphe nuclei NFTs, 133 for locus coeruleus NFTs, 132 for subcoeruleus NFTs, 138 for basis pontis NFTs, and 136 for substantia nigra NFTs because of missing data.
b
Of the 54 participants with pRBD, sample sizes were reduced to 49 for dorsal/median raphe nuclei NFTs, 51 for locus coeruleus NFTs, 50 for subcoeruleus, and 50 for basis pontis NFTs because of missing data.