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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: DNA Repair (Amst). 2020 Sep 17;96:102972. doi: 10.1016/j.dnarep.2020.102972

Fig. 1. Pathway for Transcription PreInitiation Complex (PIC) and Initiation.

Fig. 1.

After TFIID, TFIIA, TFIIB recruit Pol II, TFIIE is recruited and in turn, recruits TFIIH. TFIIE is positioned as a molecular latch, locking down TFIIH and limiting overall TFIIH flexibility. The XPB translocase will negatively supercoil the initiator element (INR) DNA to open it for Pol II. Pol II C-terminal domain (CTD) phosphorylation by the CAK kinase module in the ten-subunit TFIIH will promote Pol II release from the INR.