Fig. 9. TFIIH disease mutations mapped onto TFIIH-XPA-DNA.
A) Positions of XP, CS, and TTD disease mutations (spheres) are shown on NER TFIIH-XPA-DNA structure. Each protein or subunit are colored as in Fig. 3, except XPD is colored by domain. Note that p62 was not modeled in this structure. B,C,D) Zooms highlight general features of each type of disease mutation. Most XP mutations are at XPD DNA or ATP-binding sites. Most CS mutations are at allosteric regions that change conformation. Most TTD mutations are at protein-protein interfaces. B and D are in same perspective as A. C is oriented to highlight HD1 (blue) and HD2 (moss green) interface. Parts of XPD were removed by depth slicing for clarity.