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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Trends Pharmacol Sci. 2020 Nov 2;41(12):1050–1065. doi: 10.1016/j.tips.2020.10.004

Figure 2. Prediction of drug sensitivity at the single-cell level.

Figure 2.

(A) Tumor subpopulations maintain diverse sensitivity to different drugs. Single usage of a drug may obtain less treatment efficiency. Knowing drug sensitivity at the single-cell level can guide the development of combination treatment that maximizes the efficiency of killing tumor cells while minimizes damage to healthy cells. (B) The MRD will proliferate and differentiate into a new tumor population which induces cancer relapse. The understanding of specific signatures characterized in MRD cells can help to discover novel drugs that specifically target MRD. MRD-targeted drug(s) administered in combination with conventional treatments can cure cancer and prevent relapse.