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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Liver Int. 2020 Jul 7;40(10):2455–2468. doi: 10.1111/liv.14569

Figure 8. Working model of intercellular communication between senescent cholangiocytes and target cells.

Figure 8.

Senescent cholangiocytes release increased numbers of EVs that are likely enriched in exosomes. Compared to EVs from nonsenescent cholangiocytes, EVs from patient-derived or experimentally induced senescent cholangiocytes are increased in number, enriched in growth factors including epidermal growth factor receptor (EGFR) ligands, and have different functional effects on target cells.