Table 2.
Selected genes in liver differentially regulated following chronic plus binge ethanol feeding in mice.
| Gene symbol | Fold change | Adjusted P | Function |
|---|---|---|---|
| Tlr3 | −1.38 | 1.13E-02 | Immune response |
| Tlr5 | 1.33 | 2.17E-02 | Immune response |
| Tlr7 | −1.35 | 7.09E-02 | Immune response |
| Tlr12 | 1.48 | 8.91E-02 | Immune response |
| ll1a | 1.53 | 4.16E-02 | Inflammation |
| ll1b | 1.61 | 9.92E-02 | Inflammation |
| Pdk4 | 1.48 | 3.31E-01 | Fatty acid oxidation |
| Gpx3 | 1.93 | 4.86E-05 | Oxidative stress |
| Nqo1 | 1.44 | 1.88E-02 | Oxidative stress |
| Ppp1r3b | −1.50 | 1.46E-02 | Glucose metabolism |
| Thrsp | −4.44 | 4.15E-09 | Triglyceride biosynthesis |
| Fasn | −2.08 | 7.27E-03 | Triglyceride biosynthesis |
| Abcb11 | −1.62 | 9.20E-06 | Bile acid metabolism |
| Cyp27a1 | −1.56 | 7.38E-04 | Bile acid metabolism |
| Bcl6 | −2.08 | 1.01E-02 | Apoptosis |
| Casp3 | −1.36 | 1.28E-02 | Apoptosis |
| Casp9 | −1.37 | 1.52E-02 | Apoptosis |
| Foxm1 | −1.98 | 7.23E-04 | Cell cycle |
| Cdkn1a | 5.04 | 1.25E-03 | Cell cycle |
| Hgf | 1.92 | 1.45E-05 | Growth factor |
| Vegfa | −1.56 | 1.60E-03 | Growth factor |
| Vegfb | −1.65 | 2.74E-06 | Growth factor |