Table 1:
Characteristics of the study population at baseline visit 4 (1996–1998) and baseline visit 5 (2011–2013), the Atherosclerosis Risk in Communities (ARIC) Study cohort.
| Visit 4 (1996–1998) N = 9967 |
Visit 5 (2011–2013) N = 4626 |
|
|---|---|---|
| Age, years, mean (SD) | 62.8 (5.7) | 75.5 (5.2) |
| Female | 5701 (57.2) | 2637 (57.0) |
| African-American | 2029 (20.4) | 1003 (21.7) |
| Education | ||
| <High school | 1850 (18.6) | 599 (12.9) |
| High school or GED | 4243 (42.6) | 1908 (41.2) |
| >High school | 3874 (38.9) | 2119 (45.8) |
| Smoking | ||
| Current | 1413 (14.2) | 256 (5.7) |
| Former | 4312 (43.5) | 2165 (47.9) |
| Never | 4195 (42.3) | 1708 (37.8) |
| Apolipoprotein E4 status | ||
| TT = 0 Alleles | 6743 (69.9) | 3236 (72.2) |
| CT = 1 Allele | 2651 (27.5) | 1167 (26.1) |
| CC = 2 Alleles | 247 (2.6) | 80 (1.8) |
| Body mass index (BMI), kg/m2 | ||
| Underweight (<18.5) | 73 (0.7) | 45 (1.0) |
| Normal weight (18.5 – 25) | 2523 (25.3) | 1091 (23.5) |
| Overweight (25 – 30) | 3934 (39.5) | 1793 (38.8) |
| Obese (>30) | 3437 (34.5) | 1697 (36.7) |
| Diabetes | 1543 (15.5) | 1459 (32.3) |
| Systolic blood pressure, mmHg, mean (SD) | 133.9 (21.2) | 130.5 (18.1) |
| Antihypertensive medication | 4165 (41.8) | 3470 (75.1) |
| C-reactive protein (CRP), mg/l, median (IQR) | 2.4 (1.1, 5.4) | 2.0 (1.0 – 4.2) |
| Measures of kidney function | ||
|
Estimated Glomerular Filtration Rate (eGFR), ml/min per 1.73m2, median (IQR) |
||
| CKD-EPI, Creatinine | 89.2 (76.7, 96.2) | 70.9 (58.2, 83.0) |
| CKD-EPI, Cystatin-C | 85.2 (73.0, 97.3) | 60.9 (47.9, 74.7) |
| CKD-EPI, Creatinine + Cystatin-C | 87.3 (76.6, 97.1) | 66.1 (53.8, 78.3) |
| CKD-EPI, Beta-2-Microglobulin | 75.3 (66.4, 84.6) | 64.0 (54.0, 73.4) |
|
Urine albumin-to-creatinine ratio (UACR), mg/g Creatinine, median (IQR) |
3.7 (1.8, 7.5) | 10.3 (6.3, 21.7) |
Data are presented as number (%) unless otherwise specified.