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STS inhibitor design and selection. A. VCaP cells were treated with 5 μM STS inhibitors overnight and STS activity was determined by STS fluorometric assay. B. C4–2B cells were treated with 2.5 μM of STS inhibitors for 3 days. Total cell numbers were determined. C. SI-1 and SI-2 chemical structures and molecular weight. * p<0.05.
