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. 2020 Aug 7;108(6):1233–1242. doi: 10.1002/cpt.1982

Figure 1.

Figure 1

Manhattan plots for GWAS of AED‐MS treatment response in bipolar disorder. (a) At a SNP level, rs78835388 and rs114872993 are associated with AED‐MS response at a genome‐wide significant level (red line: P = 5E‐08). The SNP rs78835388 maps to an intron of THSD7A, while rs114872993 maps to an intergenic region between SLC35F3 and COA6. (b) At a gene level, ABCC1 and DISP1 show genome‐wide significant association with AED‐MS response (red line: P = 2.9E‐06; corrected for 17,049 protein‐coding genes). AED‐MS, antiepileptic drug–mood stabilizer; GWAS, genome‐wide association study; SNP, single‐nucleotide polymorphism.