Fig. 3.
Isolation of cell lines pLB4-progerin and pLB4-GFP. (A) pLB4-progerin cells display nuclear fluorescence due to expression of GFP-progerin. (B) pLB4-GFP cells display cytoplasmic fluorescence due to expression of GFP. (C) Western blot of whole-cell extracts from cell lines pLB4, pLB4-progerin, and pLB4-GFP (lanes labeled 1,2,3 respectively). Samples are displayed in noncontiguous lanes from the same gel. An anti-GFP primary antibody was used. Cell line pLB4-progerin displays GFP-progerin at the expected mw of ~95 kD (lane 2) while cell line pLB4-GFP displays GFP at the expected mw of ~27 kD (lane 3).