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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Trends Pharmacol Sci. 2020 Oct 20;41(12):900–908. doi: 10.1016/j.tips.2020.09.013

Figure 1. Tryptophan Intestinal Microbial Catabolites as Ligands and Agonists of Xenosensors, AhR and PXR.

Figure 1.

A chart summarizes molecular effects of known human intestinal microbial metabolites of tryptophan at AhR and PXR receptors. Heat-map shows a semi-quantitative profile of interactions: (i) AFFINITY, is a measure of compound binding at the receptor ligand binding domain (dissociation constant ≈ KD); (ii) POTENCY, refers to the concentration of the compound to produce 50% of maximal effect (half-maximal effective concentration ≈ EC50); (iii) EFFICACY is the maximum response that can be reached by the compound.