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. Author manuscript; available in PMC: 2021 May 2.
Published in final edited form as: Nat Metab. 2020 Nov 2;2(11):1332–1349. doi: 10.1038/s42255-020-00301-7

Extended Data Fig. 10: Proposed Model: PDGFRβ+ perivascular cells regulate WAT macrophage accumulation in obesity.

Extended Data Fig. 10:

FIPs are a subpopulation of PDGFRβ+ perivascular cells that are capable of exerting a pro-inflammatory phenotype. In lean (chow-fed) mice, the expression of ZFP423 in FIPs serves to moderate the activation of NFκB signaling and adipose tissue inflammation, through a molecular mechanism depicted in Fig. 8g. In response to high fat diet feeding, Zfp423 expression is reduced, facilitating the activation of NFκB signaling in FIPs and the production of pro-inflammatory cytokines/chemokines required to drive the chronic macrophage accumulation and activation that occurs during prolonged high fat diet feeding.