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. Author manuscript; available in PMC: 2021 Aug 7.
Published in final edited form as: Curr Opin Pharmacol. 2020 Aug 7;53:66–76. doi: 10.1016/j.coph.2020.07.001

Figure 1. CD73-mediated immunosuppression in the TME.

Figure 1.

CD73 serve as a major immune suppressive mediator in TME mainly through generation of extracellular adenosine. Besides the effect of cancer cell-intrinsic CD73 on tumor cell proliferation, angiogenesis, invasion/migration and metastasis, CD73 expression by tumor cells and immune cells impairs anti-tumor immunity by suppressing the function of protective immune cells (e.g. effector T cells, NK cells, DC and B cells), while maintaining the function of regulatory immune cells (e.g. Treg, MDSC, TAM and CAF).