. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: Ther Drug Monit. 2020 Dec;42(6):848–855. doi: 10.1097/FTD.0000000000000796

Table 4.

Parameter estimates from final vancomycin population pharmacokinetic model

Parameter	Point estimate	95% Confidence Interval	Relative standard error (%)
CL,^a L/hr (L/hr/kg^0.75)	4.02 (0.29)	3.6–4.2 (0.26–0.30)	5.93
V,^a L (L/kg)	16.4 (0.48)	13.8–19.0 (0.41–0.56)	8.05
eGFR from FAS_comb	0.903	0.48–1.33	24.1
Female sex	0.699	0.48–0.92	16.0
Inter-individual variability,^b
Clearance	23.4		34.9
Volume	NA		NA
Residual variability,
Proportional^c	0.179		65.1
Additive	2.44		106.0

Parameter estimates presented for a typical 34-kg male patient with an eGFR of 145 mL/min/1.73 m². Final model:

CL (L/hr) = 4.02 × (WT/34)^0.75 × (eGFR/145)^.903 × (0.699 if female)

V (L) = 16.4 × (WT/34)

Inter-individual variability point estimates are presented as percent coefficient of variation calculated by the square root of the variance × 100.

Proportional residual variability reported as standard deviation.

CL, clearance; eGFR, estimated glomerular filtration rate; FAS_comb, full age spectrum; NA, not applicable; V, volume