Table 3:
Comparison of daily symptoms in those with IH, NT2, and NT1
| IH | NT2 | NT1 | p-value | pairwise | |
|---|---|---|---|---|---|
| SYMPTOMS AT THEIR WORST | |||||
| Excessive daytime sleepiness | 457 (97.7%) | 43 (100%) | 49 (100%) | 0.55 | -- |
| Long sleep durations | 240 (51.3%) | 20 (46.5%) | 17 (34.0%) | 0.06 | -- |
| Intentional napping | 250 (53.4%) | 30 (69.8%) | 35 (71.4%) | 0.01 | IH < NT2=NT1 |
| Unintentional daytime sleep | 169 (36.2%) | 22 (51.2%) | 33 (67.4%) | <0.0001 | IH < NT1 |
| Requiring multiple alarms to awaken | 326 (69.8%) | 27 (62.8%) | 30 (61.2%) | 0.33 | -- |
| Having trouble waking up and functioning with normal alertness | 369 (79.0%) | 29 (67.4%) | 41 (82.0%) | 0.17 | -- |
| Brain fog (being unable to think clearly or concentrate at any time throughout the day) | 380 (82.6%) | 32 (74.4%) | 43 (86.0%) | 0.31 | -- |
| Difficulty remembering things | 326 (71.8%) | 27 (62.8%) | 39 (78.0%) | 0.26 | -- |
| Automatic behaviors | 100 (22.7%) | 13 (31.0%) | 19 (40.4%) | 0.02 | IH < NT1 |
| SYMPTOMS WITHIN THE LAST 30 DAYS, ON TREATMENT | |||||
| Excessive daytime sleepiness | 243 (64.1%) | 17 (44.7%) | 25 (54.4%) | 0.04 | IH > NT2 |
| Long sleep durations | 52 (13.7%) | 4 (10.5%) | 3 (6.5%) | 0.35 | -- |
| Intentional napping | 52 (13.7%) | 6 (15.8%) | 14 (31.1%) | 0.01 | IH < NT1 |
| Unintentional daytime sleep | 23 (6.1%) | 3 (7.9%) | 3 (6.7%) | 0.81 | -- |
| Requiring multiple alarms to awaken | 228 (60.3%) | 9 (23.7%) | 21 (46.7%) | <0.0001 | IH > NT2, NT1 > NT2 |
| Having trouble waking up and functioning with normal alertness | 228 (61.1%) | 14 (36.8%) | 19 (41.3%) | 0.001 | IH > NT2 = NT1 |
| Brain fog (being unable to think clearly or concentrate at any time throughout the day) | 203 (54.3%) | 10 (26.3%) | 23 (50.0%) | 0.004 | IH = NT1 > NT2 |
| Difficulty remembering things | 190 (51.5%) | 11 (29.0%) | 23 (50.0%) | 0.03 | IH > NT2 |
| Automatic behaviors | 45 (12.9%) | 5 (13.2%) | 9 (20.5%) | 0.39 | -- |