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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2020 Jun 20;53:8–17. doi: 10.1016/j.coph.2020.03.002

Figure 2. The structure of nuclear receptors.

Figure 2.

Nuclear receptors share structural homology. A-B is the N-terminal domain containing ligand-independent activation function −1 (AF-1) domain. C has the highly conserved DNA binding domain (DBD), and D is the hinge domain linking DBD to LBD. E has the Ligand binding domain (LBD) that contains AF-2, which is important for the binding of coactivators. Ligand binding to LBD causes the conformational change of nuclear receptors. F is the less conserved C-terminal domain.