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. Author manuscript; available in PMC: 2021 Nov 12.
Published in final edited form as: Cell. 2020 Oct 15;183(4):850–859. doi: 10.1016/j.cell.2020.09.044

Figure 2. Opportunities for combination therapy.

Figure 2.

A simplified schematic of KRAS signaling along with inhibitors targeting various intermediates reported to modulate KRAS(G12C) inhibition. Solid lines indicate a direct effect whereas dotted lines indicate indirect effects. Colors denote signaling intermediates along the same pathway.