Table I.
KRAS(G12C) inhibitors in clinical trials
| Drug | Status | Phase | Design | Trial |
|---|---|---|---|---|
| Sotorasib (AMG510) | Recruiting | I/II/III | Monotherapy or combination with: AMG404 (anti-PDl) Panitumumab RMC4630 Trametinib Afatinib |
NCT04380753 NCT03600883 NCT04303780 NCT04185883 |
| MRTX849 | Recruiting | I/II | Monotherapy or combination with: Pembrolizumab Cetuximab Afatinib TNO155 |
NCT03785249 NCT04330664 |
| GDC6036 | Recruiting | I | Monotherapy | NCT04449874 |
| LY3499446 | Not recruiting * | I | Monotherapy | NCT04165031 |
| JNJ74699157 | Not recruiting * | I | Monotherapy | NCT04006301 |
*
Terminated due to toxicity.