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Effects of JNK deletion on histologic measures of OA in 18 month-old mice. JNK1−/−, JNK2−/− and wild-type (WT) mice were evaluated. A, Articular cartilage structure (ACS) scores performed on the medial (MTP) and lateral (LTP) tibial plateus from six sections per joint were summed. B, Osteophytes were scored on the MTP and LTP from a mid-coronal section. Results shown are mean ± standard deviation and analysis by Mann-Whitney test comparing WT controls to each genotype.
