Fig.6:

(A) Dynamic ¹³C MRS array showing metabolism of hyperpolarized [2-¹³C]pyruvate in NHAIDHmut cell line treated with TMZ or DMSO for 72h. Inserts show the sum of all spectra within the dotted region. [2-¹³C]PYR: [2-¹³C]pyruvate, [2-¹³C]PYR hydrate: [2-¹³C]pyruvate hydrate, [1-¹³C]PYR: [1-¹³C]pyruvate, [5-¹³C]GLUT: [5-¹³C]glutamate. (B) Temporal evolution and quantification (insert) of hyperpolarized [5-¹³C]glutamate production in NHAIDHmut cell line. (C) Temporal evolution and quantification (insert) of hyperpolarized [5-¹³C]glutamate production in U87IDHmut cell line. *p-value<0.05, **p-value<0.01.