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. Author manuscript; available in PMC: 2021 May 15.
Published in final edited form as: Cancer Res. 2020 Sep 9;80(22):5121–5133. doi: 10.1158/0008-5472.CAN-19-3883

Figure 4 – Model Predictions for Variable Induction Periods:

Figure 4 –

Model predicted freedom from local failure (D), freedom from distant failure (E), and progression free survival (F) K-M curves for various induction lengths. The simulated treatment regimen is TKI induction, chemoradiotherapy, and adjuvant TKI maintenance. The local and distant tumor volume trajectory of the median simulated patient with an initial persistent fraction of 0.1 and initial resistant fraction of 0.01, stratified by TKI response cell subtypes, are shown in (A) and (B) respectively. Hazard ratios corresponding to the K-M curves (D-F) are shown in (C).