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. Author manuscript; available in PMC: 2021 May 15.
Published in final edited form as: Clin Cancer Res. 2020 Aug 26;26(22):6017–6027. doi: 10.1158/1078-0432.CCR-20-1916

Figure 3. Hedgehog pathway analysis in skin and lung tumor samples.

Figure 3.

(A, B) Transcription of GLI1 (A) and PTCH1 (B) mRNA, as a readout for Hh pathway activity, in skin biopsies before and after 10 days of itraconazole treatment is shown. All samples were normalized to the mean of respective day 0 mRNA levels. ns = not significant. (C, D) GLI1 (C) and PTCH1 (D) mRNA levels of resected lung tumors treated with itraconazole, lung tumors and normal lung from other unrelated sample sets are shown. ** P = 0.004; ns = not significant