Table 2.

Associations between pharmoacokinetic (PK) parameters and changes in tumor volume, perfusion (K^trans), angiogenic cytokines, and microvessel density.

PK Parameter	Correlative	Correlation*	P value
Itraconazole Cmax (plasma) (ng/mL)	Tumor volume Δ	−0.71	0.05
	Tumor MVD Δ	−0.69	0.03
	GM-CSF Δ	−1.00	<0.001
	IFN-γ Δ	1.00	<0.001
Itraconazole AUC0–4h (plasma) (ng∙mL/hr)	Tumor volume Δ	−0.63	0.009
	Tumor MVD Δ	−0.67	0.03
	IL-1β Δ	−0.73	0.01
	IFN-γ Δ	1.00	<0.001
Hydroxyitraconazole Cave (plasma) (ng/mL)	Tumor volume Δ	−0.71	0.05
	IL-1β Δ	−0.78	0.005
	IFN-γ Δ	1.00	<0.001
Itraconazole concentration (tissue) (ng/mL)	Tumor volume Δ	−0.59	0.04
	Tumor Ktrans Δ	−0.71	0.01
	Tumor MVD Δ	−0.69	0.06

AUC_0–4h, area under the curve calculated from 0 to 4 hours; GM-CSF, granulocyte macrophage colony stimulating factor; IFN, interferon; MVD, microvessel density

^*Spearman rank correlation