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. 2020 Nov 3;8:553444. doi: 10.3389/fcell.2020.553444

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Copyright © 2020 de Almeida Fuzeta, Bernardes, Oliveira, Costa, Fernandes-Platzgummer, Farinha, Rodrigues, Jung, Tseng, Milligan, Lee, Castanho, Gaspar, Cabral and da Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Size distribution of MSC-EVs. (A) Representative size distribution curves of EV samples obtained from BM, AT, and UCM MSC, cultured in static or Vertical-Wheel^TM bioreactor systems. (B) Box plots representing the size distribution profiles of EV samples obtained from BM, AT, and UCM MSC, cultured in static or Vertical-Wheel^TM bioreactor systems. The minimum, 1st quartile, median, 3rd quartile and maximum values are represented for each condition. MSC from three different donors were used for each tissue source (i.e., n = 3 biological replicates). BM, bone marrow; AT, adipose tissue; UCM, umbilical cord matrix.