Table 2.

The results before and 4, 8, 12 weeks after treatment with LipiFlow® in the HMGD group

Project	N	Baseline	4 weeks			8 weeks			12 weeks
		$\overline{x}\pm s$	$\overline{x}\pm s$	t	P4	$\overline{x}\pm s$	t	P8	$\overline{x}\pm s$	t	P12
SPEED	25	12.12 ± 2.45	8.92 ± 2.14	13.443	< 0.001*	6.64 ± 1.68	16.784	< 0.001*	5.20 ± 1.96	18.086	< 0.001*
OSDI	25	24.12 ± 4.84	17.31 ± 4.71	2.394	< 0.001*	13.86 ± 4.21	14.276	< 0.001*	12.92 ± 4.12	15.95	< 0.001*
SIT/mm	25	1.48 ± 1.00	3.88 ± 1.17	− 7.719	< 0.001*	2.88 ± 1.27	− 4.427	< 0.001*	2.00 ± 1.35	− 1.641	0.114
NIKBUT/s	25	3.17 ± 1.40	5.49 ± 1.57	− 7.653	< 0.001*	3.77 ± 1.27	− 2.902	0.008*	2.95 ± 1.14	1.208	0.239
TMH/mm	25	0.19 ± 0.09	0.24 ± 0.09	− 19.092	< 0.001*	0.22 ± 0.09	− 10.533	< 0.001*	0.20 ± 0.09	− 4.301	< 0.001*
LLT/nm	25	44.40 ± 9.45	46.44 ± 9.79	− 8.981	< 0.001*	45.32 ± 9.75	− 2.326	0.029*	44.72 ± 9.16	− 0.969	0.342
PBR	25	0.61 ± 0.19	0.51 ± 0.17	13.843	< 0.001*	0.42 ± 0.15	16.794	< 0.001*	0.42 ± 0.14	13.913	< 0.001*

$\overline{x}\pm s$: mean ± standard deviation; P₄: P value at 4 weeks from baseline; P₈: P value at 8 weeks from baseline; P₁₂: P value at 12 weeks from baseline

SPEED Standard Patient Evaluation of Eye Dryness, OSDI Ocular Surface Disease Index, SIT Schirmer I test, NIKBUT noninvasive keratographic breakup time, TMH tear meniscus height, LLT lipid layer thickness, PBR partial blink rate

*Statistically significant