Fig. 2.

a The D group had a higher body weight gain from week one (P < 0.001). At week eight, half of the D animals switched from the HFD to the control diet, and all were divided into surgery groups NS, Sham or VSG. At week 12, VSG had a significantly lower BWG than Sham or NS in the same diet group, especially for D + C (P < 0.001). b Different parameters at week 12. The adiposity index was lowered by the combination of VSG and diet switch. Leptin was affected by VSG. Ghrelin was reduced in D groups. Insulin Sensitivity Index increased in D + C-VSG. No significant changes were seen in Insulin or HOMA-IR. P values < 0.001 (***) and a–c correspond for significantly different groups (Tukey post-test)