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. 2020 Feb 17;59(8):3669–3689. doi: 10.1007/s00394-020-02200-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of B. coagulans spores, GBRS and synbiotic treatments on DSS-induced colonic tissue injury. a Histological images of proximal and distal colonic tissues stained with hematoxylin and eosin at × 20 for each experimental group. b Histological score calculated after microscopic analyses of proximal and distal sections of the colon. c Myeloperoxidase (MPO) activity in colonic tissues was determined by colorimetric assay. Results, expressed as mean ± SEM (n = 8 per group), were evaluated by one-way ANOVA followed by Tukey’s test (*p < 0.05, **p < 0.01, ****p < 0.0001)