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. 2020 Nov 16;11:5823. doi: 10.1038/s41467-020-19452-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a H3K27ac ChIP-seq fold change over input (left) and size-factor normalized MYCN expression as determined from RNA-seq for 12 non-MYCN-amplified neuroblastoma cell lines. b Aggregated H3K27ac signal of MYCN-expressing compared to non-expressing cells (top, black; MYCNp, MYCN promoter; e1–e5, MYCN-specific enhancers). PHOX2B, GATA3, and HAND2 core regulatory circuit transcription factor ChIP-seq in an MYCN-expressing neuroblastoma cell line (green, CLB-GA). Source data are provided as a Source Data file.