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. 2020 Nov 16;11:5823. doi: 10.1038/s41467-020-19452-y

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© The Author(s) 2020

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Fig. 7 — In most cases, MYCN and its local gene-regulatory neighborhood including a CRC-driven super-enhancer is amplified (Class I). If the local neighborhood is not co-amplified, amplicons are more complex and recruit distal gene-regulatory elements (Class II).

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