Table 3.
Comparison of hormone receptor status (HER2 and AR) and tumor immune microenvironment characteristics (TILs and PD-L1) in groups with different FISH findings
| Monosomy or normal (N = 7) | Aneusomy or ERBB2 amplification (N = 25) | p-value | |
|---|---|---|---|
| Age (years) | p = 0.562 | ||
| Mean (SD^) | 57.3 (14.75) | 62.29 (11.95) | |
| Median | 66 | 65 | |
| Range | 35–69 | 35–87 | |
| Tumor size (cm) | p = 0.153 | ||
| Mean (SD) | 2.53 (1.5) | 3.18 (1.45) | |
| Median | 2 | 2.7 | |
| Range | 1.2–5.5 | 1.3–6.5 | |
| Histologic type | p = 1.000 | ||
| SDC | 3 | 13 | |
| SDC/carcinoma ex PA | 4 | 12 | |
| HER2 salivary gland (N) | p < 0.01 | ||
| 0 | 7 | 0 | |
| 1 | 0 | 4 | |
| 2 | 0 | 2 | |
| 3 | 0 | 19 | |
| HER2:CEP17 ratio | p < 0.01 | ||
| Mean (SD) | 1.02 (0.11) | 4.5 (2.56) | |
| Range | 0.95–1.26 | 0.97–10.39 | |
| AR status (N) | |||
| Negative | 0 | 0 | |
| Positive | 7 | 25 | |
| TILs (%) | p = 0.045 | ||
| Mean (SD) | 11.83 (9.06) | 26.18 (17.11) | |
| Range | 1–25 | 1–70 | |
| PD-L1 status (N) | p = 0.025 | ||
| Negative | 7 | 12 | |
| Positive | 0 | 13 |
SD standard deviation, SDC salivary duct carcinoma, PA pleomorphic adenoma