Table 1.
Patient 1 | Patient 2 | Patient 3 | |
---|---|---|---|
Sex/age | Male/63 | Female/72 | Female/55 |
Hematologic diagnosis | Multiple myeloma and AL amyloidosis – lambda light chains | Multiple myeloma and AL amyloidosis – lambda light chains | Multiple myeloma and AL amyloidosis – lambda light chains |
Time from symptom onset to diagnosis | 5 months | 6 months | 5 months |
Extracardiac involvement | Kidney, tongue, skin, heart | Tongue, liver, kidney, heart | Tongue, liver, kidney, heart |
NT-proBNP | 13 900 ng/L | 10 940 ng/L | 5225 ng/L |
hs-TnI | 92.9 ng/L | 138.4 ng/L | 53.6 ng//L |
Left ventricle size (EDV/ESV) | 80 mL/40 mL | 43 mL/27 mL | 77 mL/28 mL |
Left ventricular mass index | 122 g/m2 | 133 g/m2 | 120 g/m2 |
Septal thickness | 15 mm | 15 mm | 13 mm |
EF | 50% | 37% | 37% |
GLS | −7% | −6% | −9% |
RRSR | – | 1.48 | 1.47 |
EF/GLS ratio | 7.1 | 6.2 | 4.2 |
Diastolic function | |||
E vel | 1.3 m/s | 1.1 m/s | 0.84 m/s |
A vel | 0.36 m/s | 0.38 m/s | 0.4 m/s |
E/A | 3.1 | 2.8 | 2.2 |
DecT | 149 ms | 162 ms | 176 ms |
E/e’ | 28 | 38 | 21 |
A vel – A velocity; AL – primary amyloidosis; DecT – mitral inflow deceleration time; E/A – ratio of the early diastole (the E wave) to peak velocity flow in late diastole caused by atrial contraction (the A wave); EDV – end-diastolic volume; E/e’ – ratio between early mitral inflow velocity and mitral annular early diastolic velocity; EF – ejection fraction; ESV – end-systolic volume; E vel – E velocity; GLS – global longitudinal strain; hs-Tnl – highly sensitive troponin; NT-proBNP – N-terminal pro b-type natriuretic peptide; RRSR – relative regional strain ratio.