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. 2020 Nov 3;11:536442. doi: 10.3389/fimmu.2020.536442

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Copyright © 2020 Smith, Culver-Cochran, Adelman, Rhyasen, Ma, Figueroa and Starczynowski

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A20 expression is reduced in aged human and mouse HSC. (A) UCSC genome browser tracks of active enhancers within the TNFAIP3/A20 locus that overlap ChIP-seq peaks. Tracks are of pooled replicates for each age group, normalized to reads per million and to the corresponding input. Y, young; A, aged. (B) Quantification of the peak height from Figure 1A for H3K27ac within enhancers (E) 1-4 or H3K4me3 within the promoter (P). *P < 0.05; ***P < 0.001. (C) RNA-seq gene expression analysis of TNFAIP3 (A20) in young (n = 10) and aged (n = 10) HSCe (Lineage^-CD34⁺CD38^-). (D) Tnfaip3 (A20) mRNA expression in young and old LSK BM cells by qRT-PCR (n = 6 and 5 per group, respectively). *P < 0.05. Data are represented as mean ± standard deviation.