Table 3.
Analysis showing that CFH–H3 and CD46GGAAC haplotypes are not associated with CD46 c.286+2T>G rare variant.
| CFH–H3 haplotype | CD46 c.*897T>C | |||||||
|---|---|---|---|---|---|---|---|---|
| Status | het | hom | No CFH H3-haplotype | Total subjects screened | TT | TC | CC | Total subjects screened |
| Affected | 3 | 3 | 3 | 9 | 0 | 1 | 10 | 11 |
| Unaffected | 7 | 1 | 5 | 13 | 0 | 6 | 7 | 13 |
| P = 0.293 | P = 0.124 | |||||||
Patients and relatives carrying the CD46 c.286+2T>G rare variant were genotyped for CFH single-nucleotide polymorphisms (SNPs) and for the CD46 SNP (rs7144; c.*897T>C) tagging the CD46GGAAC haplotype.