Fig. 5.

Thymic‐derived and peripherally induced CD4⁺CD25^high regulatory T cells (T_reg) in acute Kawasaki disease (KD) subjects. To study regulation by the adaptive immune system in KD subjects, we measured CD4⁺CD25^high T_reg in total peripheral blood mononuclear cells (PBMC) and the expression of interleukin‐17 receptor (IL‐7R) to identify thymic‐derived (IL‐7R⁻) and peripherally induced (IL‐7R⁺) T_reg. (a) Representative fluorescence activated cell sorter (FACS) plots of thymic‐derived and peripherally induced T_reg from KD subject 10. Percentage of CD4⁺CD25^high T_reg in total PBMC and IL‐7R expression is shown. (b) Percentage of CD4⁺CD25^high T_reg in total PBMC from the 17 KD subjects. Subject numbers (Table 1) are shown with the percentage of of PBMC or T_reg in parentheses. (c) Percentage of CD4⁺CD25^high T_reg expressing IL‐7R (peripherally induced T_reg). The data are shown as scatter‐plots with median and interquartile range.