Table 3.

Univariate and Multivariate Cox Regression Analyses of Risk Factors Associated with Disease-Free Survival in SYSU HCC and TCGA-LIHC Cohort

Variables	Univariate Analysis		Multivariate Analysis
SYSU HCC cohort (n=100)	HR (95% CI for HR)	P value	HR (95% CI for HR)	P value
Gender	2.28 (0.816–6.39)	0.116
Age	1.11 (0.621–1.98)	0.728
TNM stage	3.26 (1.76–6.06)	< 0.001	2.465 (1.233–4.926)	0.011
HBV infection	1.54 (0.838–2.82)	0.164
Tumor number	0.396 (0.221–0.711)	0.002	0.759 (0.385–1.498)	0.427
Tumor size	3.41 (1.77–6.59)	< 0.001	1.924 (0.966–3.835)	0.063
Tumor thrombus	2.96 (1.65–5.3)	< 0.001	1.379 (0.704–2.701)	0.349
AFP level	2.36 (1.3–4.3)	0.005	0.915 (0.44–1.904)	0.813
Differentiation grade	0.488 (0.273–0.87)	0.015	0.86 (0.447–1.653)	0.65
GIHCG expression level	0.262 (0.129–0.53)	< 0.001	0.365 (0.161–0.828)	0.016
TCGA LIHC cohort (n=345)	HR (95% CI for HR)	P value	HR (95% CI for HR)	P value
Gender	0.933 (0.673–1.29)	0.679
Age	0.991 (0.682–1.44)	0.963
TNM stage	2.21 (1.6–3.07)	< 0.001	1.312 (0.318–5.415)	0.708
T stage	2.21 (1.59–3.07)	< 0.001	1.573 (0.378–6.542)	0.534
HBV/HCV infection	1.45 (1.07–1.98)	0.018	1.379 (1.009–1.884)	0.044
AFP level	0.971 (0.651–1.45)	0.886
Differentiation grade	1.15 (0.841–1.57)	0.380
GIHCG expression	0.619 (0.454–0.844)	0.002	0.666 (0.486–0.911)	0.011