Table 1.
Baseline characteristics of study participants
| Discovery set (n=701) | Replication set (n=278) | |||||
|---|---|---|---|---|---|---|
| Normal BMD (n=413) |
Osteopenia (n=205) |
Osteoporosis (n=83) |
Normal BMD (n=103) |
Osteopenia (n=68) |
Osteoporosis (n=107) |
|
| Age, years | 52.9 ± 12.0 | 59.0 ± 10.8 | 63.0 ± 9.1 | 62.6 ± 12.7 | 66.5 ± 13.9 | 70.3 ± 9.5 |
| Women, n (%) | 193 (46.7) | 117 (57.1) | 59 (71.1) | 45 (43.7) | 53 (77.9) | 92 (86.0) |
| Menopause, n (%) | 88 (45.6) | 103 (88.0) | 59 (100.0) | 32 (71.1) | 49 (92.5) | 90 (97.8) |
| BMI, kg/m2 | 24.7 ± 3.2 | 24.2 ± 3.3 | 22.8 ± 2.9 | 24.3 ± 3.7 | 23.2 ± 3.2 | 22.4 ± 3.7 |
| CTX-I, ng/ml | 0.3 ± 0.2 | 0.3 ± 0.3 | 0.4 ± 0.3 | - | - | - |
| Spine BMD, g/cm2 | 1.2 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 1.2 ± 0.2 | 0.9 ± 0.1 | 0.7 ± 0.1 |
| Hip BMD, g/cm2 | 1.1 ± 0.1 | 1.1 ± 0.2 | 1.1 ± 0.1 | - | - | - |
Values are means ± SDs unless otherwise indicated. Menopause information missing in 24 participants in the discovery set and 1 in the replication set. CTX-I missing in 46 participants in the discovery set. Spine BMD missing in 72 participants in the discovery set. Hip BMD missing in 606 participants in the discovery set.
P values were from analysis of variance for continuous variables and chi-square test for categorical variables. All P values except for hip BMD were <0.05.
BMI, body mass index; CTX-I, C-terminal telopeptide of type I collagen; BMD, bone mineral density.