Fig. 3.

(A) Development of microprocessor power, given in million floating point operations per second (mFLOPS) (filled circles) and average time required to solve (empty squares) or optimize (filled squares) a reference ODE (ordinary differential equation) system starting from the 1980s. The reference ODE system consists of 11 equations and 36 parameters 19 solved using MATLAB ode15s package and fminsearch 5 parameter optimization with initial deviations of 20% from the final values. (B) Price development in USD for local data storage equivalent to 100 E. coli genomes (filled circles) in comparison to the average annual budget of an NIH principal investigator (grey bars). Data and specifications are listed as additional section before the references.