Table 3.

Effect of ligation on mice sensitivity to warm plate stimulation. (table based on day of observation).

Observation day	N	Onset Thermal Hyperalgesia x ± SD (second)
		Estrogen group	Placebo group	Negative control
Day-1	6	29.71 ± 12.94ab	29.81 ± 6.82a	29.82 ± 12.75a
Day-3	6	28.40 ± 10.35b	22.58 ± 11.48ab	26.01 ± 13.65a
Day-5	6	20.17 ± 11.58a	16.92 ± 7.95bc	18.03 ± 9.14ab
Day-7	6	21.05 ± 15.15ab	11.07 ± 2.83c	15.23 ± 8.58bc
Day-14	6	9.49 ± 4.76c	11.11 ± 2.83c	11.46 ± 5.10c
Same subject ANOVA		p = 0,000	p = 0,002	p = 0,001

Note: a-c: Different superscripts indicate there are differences between groups. (based on the results of paired t-test analysis).