Table 1.
List of equivalent functional proteins and processes in synaptic and BBB exocytosis.
| Equivalent protein or process | Synaptic exocytosis [7,8] | BBB exocytosis [9,10] |
|---|---|---|
| Synaptosomal Associated Protein (SNAP) | SNAP25 | SNAP23 |
| Vesicle Associated Membrane Protein (VAMP) | VAMP2 | VAMP8 |
| Syntaxin Protein | Syntaxin1 | Syntaxin2 |
| Calcium Sensor Protein | Synaptotagmin 1 (Syt1) | Synaptotagmin-like protein4-a (Slp4-a) |
| Syntaxin-binding Protein | Mammalian Uncoordinated 18–1 (Munc18-1) | Munc18-1 |
| First protein bridge for vesicle docking with the cell membrane | Munc13-1 connects to lipids | Munc13-4 connects to Annexin complex |
| Second protein bridge for vesicle docking with the cell membrane | Connection between Syt1, CAPS (Calcyphosin) and Munc18-1 | Connection between Slp4-a and Munc18-1 |
| SNAREs (SNAP REceptor) complex formed at the priming stage | Consist of SNAP25, VAMP2, and Syntaxin1 | Consist of SNAP23, VAMP8 and Syntaxin2 |