Figure 6.

T. gondii Subcellular Compartments Show Distinct Distributions of the Functional Redundancy of the Proteomes, Selection Pressure, and Genetic Polymorphism

(A) Compartment-specific distribution of protein functional redundancy expressed as the average gene knockout (KO) phenotype score quantifying the contribution of each T. gondii gene to the parasite fitness during in vitro culture (a negative score indicates relatively indispensable genes; a positive score indicates dispensable genes).

(B) Compartment-specific distributions of evolutionary selection pressures expressed as the protein-average ratio of nonsynonymous and synonymous mutation rates (d_N/d_S ratio).

(C) Compartment-specific distributions of genetic polymorphism expressed as the density of SNP per kilobase of gene coding sequence (CDS).

Compartment-specific distributions are shown as Tukey box plots as for Figure 3F.

See also Figure S7; Tables S6B–S6D.